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Cerebral blood flow variability in fibromyalgia syndrome: Relationships with emotional, clinical and functional variables.PLOS ONE September 20, 2018
Montoro CI, Duschek S, Schuepbach D, Gandarillas M, Reyes del Paso GA

Cerebral blood flow modulations during preparatory attention and proactive inhibition.Biological Psychology. 137:65-72, 2018
Duschek S, Hoffmann A, Montoro C, Schuepbach D, Reyes del Paso GA, Ettinger U

Efficacy of Continuation/Maintenance Electroconvulsive Therapy (c/mECT) in the Treatment of Patients with Mood Disorders: A Retrospective Analysis
J ECT. 2018 Oct 20. doi: 10.1097/YCT.0000000000000547. [Epub ahead of print)
Hausmann A, Post T, Post F, Dehning J, Kemmler G, Grunze H

Testing a Clinical Staging Model for Bipolar Disorder using Longitudinal Life Chart Data
Bipolar Disord. 2018 Nov 17. doi: 10.1111/bdi.12727. [Epub ahead of print]
van der Markt A; Klumpers U, Draisma S, Dols A, Nolen WA, Post RM, Altshuler L, Frye MA, Grunze H, Keck P, McElroy SL,  Suppes T, Beekman TF, Kupka R

Revising DSM-5 criteria for the bipolar disorders: Phase I of the AREDOC project
Aust N Z J Psychiatry. 2018 Oct 31:4867418808382. doi: 10.1177/0004867418808382. [Epub ahead of print]
Parker G, Tavella G, Macqueen G, Michael Berk M, Grunze H , Deckersbach T, Dunner DL, Sajatovic M, Amsterdam JD , Ketter TA, Yatham LN, Kessing LV ,Bassett  D, Zimmerman M, Fountoulakis KN , Duffy A , Alda M, Calkin C, Sharma V, Anand A, Singh MK,  Hajek T, Boyce P, Frey BN , Castle DJ, Young AH, Vieta E, Rybakowski JK, Swartz HA, Schaffer A, Murray G, Bayes A, Lam RW, Bora E, Post RM, Ostacher MJ, Lafer B, Cleare AJ, Burdick KE, O’Donovan C, Ortiz A, Henry C, Kanba S, Rosenblat JD, Parikh SV, Bond DJ, Grunebaum MF, Frangou S, Goldberg JF, Orum M, Osser DN, Frye MA, McIntyre RS, Fagiolini A, Manicavasagar V, Carlson GA, Malhi GS

More Assortative Mating in Parents and Spouses of US Compared to European Patients with Bipolar Disorder: Implications for psychiatric illness in the offspring
Eur Arch Psychiatry Clin Neurosci. 2018 Aug 11. doi: 10.1007/s00406-018-0934-y. [Epub ahead of print] PMID: 30099616
Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE, Nolen WA

The use of (newer) antipsychotics in bipolar inpatients over a seventeen year observation period
Int Clin Psychopharmacol. 2018;33(6):297-303. PMID: 30095482
Dehning J, Grunze H, Walpoth-Niederwanger M, Kemmler G, Hausmann A

Treatment-resistant and Multi-therapy resistant criteria for bipolar depression: An international consensus definition
Br J Psychiatry 2018, in press
Hidalgo-Mazzei D, Berk M, Cipriani A, Cleare A, Di Florio A, Dietch D, Geddes J,  Goodwin GM, Grunze H, Hayes JF,  Jones I, Kasper S,  Macritchie K, McAllister-Williams H; Morriss R, Nayrouz S, Pappa S, Soares JC, Smith  DJ, Suppes T, Talbot P, Vieta E, Watson S, Yatham LN, Young AH, Stokes PRA

Multigenerational transmission of liability to psychiatric illness in offspring of parents with bipolar disorder
Bipolar Disord. 2018 Jun 21. doi: 10.1111/bdi.12668. [Epub ahead of print]
PMID:  29926532
Post R, Altshuler L, Kupka R, McElroy S,  Frye M,  Rowe M,  Grunze H, Suppes T, Keck P, Leverich G, Nolen W

Axis II Personality Disorders Are Linked to an Adverse Course of Bipolar Disorder
J. Nervous Mental Dis 2018; 206(6):469-472
PMID: 29781886
Post R, McElroy S, Kupka R, Suppes T, Hellemann G, Nolen W, Frye M, Keck P, Grunze H, Rowe M

Prevalence of axis II comorbidities in bipolar disorder: relationship to mood stateBipolar Disorders 2018;20:303–312PMID: 29369448Post R, Leverich G,  McElroy S, Kupka R, Suppes T, Altshuler L,  Nolen W, Frye M, Keck P, Grunze H, Hellemann G

Switching from oral atypical antipsychotic monotherapy to paliperidone palmitate once-monthly in non-acute patients with schizophrenia: A prospective, open-label, interventional studyPsychopharmacology. 234:3-13. 2017Schreiner A, Caspi A, Bergmans P, Cherubin P, Keim S., Lara E, Pinchuk I, Schuepbach D, Suleman S, Hargarter L

The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder
Int J Bipolar Disord. 2017;5(1):31
PMID: 28944443
Riemann G, Weisscher N, Post RM, Altshuler L, McElroy S, Frye MA, Keck PE Jr, Leverich GS, Suppes T, Grunze H, Nolen WA, Kupka RW

Bupropion Maintenance Treatment in Refractory Bipolar Depression: A Case Report
Clin Pract Epidemiol Ment Health. 2017;13:43-48
PMID: 28659991
Dehning J, Grunze H, Hausmann A.

Meta-Analysis of the Risk of Subsequent Mood Episodes in Bipolar Disorder
Psychother Psychosom. 2017;86(2):90-98
PMID: 28183076
Radua J, Grunze H, Amann BL

More childhood onset bipolar disorder in the United States than Canada or Europe: Implications for treatment and prevention
Neurosci Biobehav Rev. 2017;74 (Pt A):204-213
PMID: 28119069
Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Leverich GS, Nolen WA

Illnesses in siblings of US patients with bipolar disorder relate to multigenerational family history and patients severity of illness
J Affect Disord. 2017;207:313-319
PMID: 27741468
Post R, Altshuler L,  Kupka R, McElroy S, Frye M, Rowe M, Grunze H, Suppes T, Keck P, Nolen W

Neuropsychological study of IQ scores in Offspring of parents with Bipolar I Disorder
Cognitive Neuropsychiatry 2017, 22(1), 17-27
PMID: 27855540
Camilleri N, Sharma A, Grunze H, Barron E, LeCouteur J, Close A, Rushton S, Kelly T, Ferrier IN,  LeCouteur A

Determinants of cerebral hemodynamics during the Trail Making Test in schizophrenia
Brain and Cognition. 109, 96-104. 2016
Schuepbach D, Egger ST, Boeker H, Duschek S, Vetter S, Seifritz E, Herpertz SC

Facial emotion labelling in unaffected offspring of adults with Bipolar I Disorder
J Affect Disord. 2016;208:198-204
Sharma A, Barron E, Le Couteur J, Close A, Rushton S, Grunze H, Kelly T, Ferrier N, Le Couteur A

Incidence, Characteristics and Course of Narrow Phenotype Paediatric Bipolar I Disorder in the British Isles
Acta Psychiatr Scand. 2016 , 134 (6), 522-532
PMID: 27744649
Sharma A, Neely J, Camilleri M, James A, Grunze H, Le Couteur A

Further Evidence of a Cohort Effect in Bipolar Disorder: More Early Onsets and Family History of Psychiatric Illness in More Recent Epochs
J Clin Psychiatry 2016;77 (8), 1043-1049
PMID: 27379705
Post RM, Kupka R, Keck PE Jr, McElroy SL, Altshuler LL, Frye MA, Rowe M, Grunze H, Suppes T, Leverich GS, Nolen W

Clinical correlates of sustained response to individual drugs used in naturalistic treatment of patients with bipolar disorder
Compr Psychiatry. 2016;66:146-156
PMID: 26995248
Post RM, Leverich GS, Kupka R, Keck PE Jr, McElroy SL, Altshuler LL, Frye MA, Rowe M, Grunze H, Suppes T, Nolen WA

Age at Onset of Bipolar Disorder Related to Parental and Grandparental Illness Burden
J Clin Psychiatry. 2016;77(10):e1309-e1315
PMID: 27631141
Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Leverich GS, Nolen WA

Age of onset of bipolar disorder: Combined effect of childhood adversity and familial loading of psychiatric disorders
J Psychiatr Res. 2016;81:63-70
PMID: 27392070
Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE Jr, Leverich GS, Nolen WA

Depression in bipolar disorder: prevalence rate and clinical correlates during naturalistic
In the Stanley Bipolar Network American Journal of Psychiatry, 
Am J Psychiatry 2016;173(10):1015-1023
Miller S, Mintz,J, Hellermann G, McElroy S, Nolen W, Kupka R, Leverich G, Grunze H, Altshuler L, Post R. Mixed

More illness in offspring of bipolar patients from the U.S. compared to Europe
J Affect Disord. 2016 Feb;191:180-186
Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Rowe M, Grunze H, Suppes T, Keck PE, Leverich GS, Nolen WA

Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial
Lancet Psychiatry. 2016 Feb;3(2):117-2
McAllister-Williams RH, Anderson IM, Finkelmeyer A, Gallagher P, Grunze HC, Haddad PM, Hughes T, Lloyd AJ, Mamasoula C, McColl E, Pearce S, Siddiqi N, Sinha BN,  Steen N, Wainwright J, Winter FH, Ferrier IN, Watson S; ADD Study Team

A Bipolar II Cohort (ABC): the association of functional disability with gender and rapid cycling
J.Affect.Dis 2015;185:204-8
Scott J, Grunze H, Meyer T, Nendick J, Watkins H, Ferrier IN

Multigenerational Positive Family History of Psychiatric Disorders is Associated with a Poor Prognosis in Bipolar Disorder
The Journal of Neuropsychiatry and Clinical Neurosciences 2015; 27(4):304-10
Post  RM, Leverich GS, Kupka R, Keck P, McElroy SL, Altshuler LL, Frye MA, Rowe M, Grunze H, Suppes T, Nolen WA

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: Experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I
Journal of Affective disorders 2015;174:70-82
Grunze H, Kotlik E, Costa R, Nunes T, Falcão A, Almeida L, Soares-da-Silva P.

Verbal, like Physical and Sexual, Abuse in Childhood Is Associated with an Earlier Onset and More Difficult Course of Bipolar Disorder
Bipolar Disord. 2015, 17(3):323-30
Post RM, Altshuler L, Kupka R, McElroy S, Frye MA, Rowe M,  Leverich GS,  Grunze H, Suppes T, Keck P, Nolen WA

Relationship of clinical course of illness variables to medical comorbidities in 900 adult outpatients with bipolar disorder
Comprehensive Psychiatry 2015, 56:21-8
Post RM, Altshuler L, Leverich GS, Frye MA, Suppes T, McElroy S, Keck P, Nolen WA, Kupka R, Grunze H, Rowe M

Randomised controlled trial of Antiglucocorticoid augmentation (metyrapone) of antiDepressants in Depression (ADD Study)
NIHR Journals Library; 2015 Jun
Ferrier IN, Anderson IM, Barnes J, Gallagher P, Grunze HCR, Haddad PM, House AO, Hughes T, Lloyd AJ, Mamasoula C, McColl E, Pearce S, Siddiqi N, Sinha B, Speed C, Steen N, Wainwright J, Watson S, Winter FH, McAllister-Williams R

The association of interoceptive awareness and alexithymia with neurotransmitter concentrations in insula and anterior cingulate
Social Cognitive and Affective Neuroscience. 9, 857-863. 2014
Ernst J, Böker H, Hättenschwiler J, Schuepbach D, Northoff G, Seifritz E, Grimm S

Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders
J. Affect. Dis. 2014; 168:439-51
Calabrese R, Fava M, Garibaldi G, Grunze H, Krystal A, Laughren T, Macfadden W, Marin R, Nierenberg A, Tohen M

Saving time and money: a validation of the self ratings on the prospective NIMH life-chart method (NIMH-LCM)
BMC Psychiatry 2014; 14:130 (7 May 2014)
Born C, Amann BL, Grunze H, Post RM, Schärer L

More Pernicious Course of Bipolar Disorder in the United States than in Many European Countries: Implications for policy and treatment
J.Affect.Dis 2014;160:27-33
Post RM, Altshuler L, Kupka R, McElroy S, Frye MA, Rowe M,  Leverich GS,  Grunze H, Suppes T, Keck P, Nolen WA

Phenomenology of Manic Episodes According to the Presence or Absence of Depressive Features as Defined in DSM-5: Results from the IMPACT Self-reported Online Survey
J.Affect.Dis 2014; 156, 206-213
Vieta E, Grunze H, Azorin JM, Fagiolini A

Increased parental history of bipolar disorder in the United States: association with early age of onset
Acta Psychiat Scand 2014;129(5):375-382
Post RM, Leverich GS, Kupka R, Keck P, McElroy S, Altshuler L, Frye MA, Luckenbaugh DA, Rowe M, Grunze H, Suppes T, Nolen WA

Polypharmacy and bipolar disorder: what's personality got to do with it? Int J Neuropsychopharmacol.
2014 Jul;17(7):1053-61
Sachs GS, Peters AT, Sylvia GS, Grunze H

Family Environment of Bipolar Families: A UK study
J Affect.Disord.,2014; 152-154:522-525
Barron E, Sharma A, Le Couteur J, Rushton S, Close A, Kelly T, Grunze H, Ferrier IN, Le Couteur A

Ziprasidone - Not Haloperidol - Induces more de-novo Neurogenesis of Adult Neural Stem Cells Derived from Murine Hippocampus
Pharmacopsychiatry. 2013; 46(1):10-5Pharmacopsychiatry. 2013; 46(1):10-5
Benninghoff J, Grunze H, Schindler C, Genius J, Schlösser RJ, van der Ven A, Dehning S, Wiltfang J, Möller HJ, Rujescu D. 

Study protocol for the randomised controlled trial: Antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study)
BMC.Psychiatry. 2013;13:205
McAllister-Williams RH, Smith E, Anderson IM, Barnes J, Gallagher P, Grunze HC, Haddad P,  House AO, Hughes T, Lloyd AJ , McColl EM, Pearce SH, Siddiqi N, Sinha B, Speed C, Steen IN, Wainright J,  Watson S, Winter FH, Ferrier IN

Comparably high retention and low relapse rates in different subpopulations of bipolar patients in a German non-interventional study
BMC Psychiatry,2013; 13:193
Krämer S, Minarzyk A, Eppendorfer S, Henneges C, Hundemer HP, Wilhelm St, Grunze H

More stressors prior to and during the course of bipolar illness in patients from the United States compared with the Netherlands and Germany
Psychiatry Res, 2013; 210,880-886
Post RM, Altshuler L, Leverich G, Nolen W, Kupka R, Grunze H, Frye M, Suppes T, McElroy S, Keck P, Rowe M

The potential role of Marginal Structural Models (MSMs) in testing the effectiveness of antidepressants in the treatment of patients with major depression in everyday clinical practice
World J Biol Psychiatry. 2013; 14, 386-395
Severus E, Lipkovich I, Seemüller F, Obermeier M, Grunze H, Bernhard B, Dittmann S, Riedel M, Möller HJ

Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
J Affect Disord. 2013; 147:288-294
Post RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M

Interpreting magnetic resonance imaging findings in bipolar disorder
CNS Neurosci Ther. 2012; 18(3):201-7
Cousins DA, Grunze H.

Cerebral blood flow dynamics during pain processing in patients with fibromyalgia syndrome
Psychosomatic Medicine, 74, 802-809, 2012
Duschek S, Mannhart T, Winkelmann A, Merzoug K, Werner NS, Schuepbach D, Montoya P

Sustained cognitive impairments after clinical recovery of severe depression
Journal of Nervous and Mental Disease, 200, 773-776. 2012
Boeker H, Schulze J, Richter A, Nikisch G, Schuepbach D, Grimm S

Gender and rapid alterations of hemispheric dominance
Neuropsychobiology, 66, 149-157. 2012
Schuepbach D, Skotchko T, Duschek S, Theodoridou A, Grimm S, Böker H, Seifritz E

Treatment patterns in inpatients with bipolar disorder at a psychiatric university hospital over a 9-year period: focus on mood stabilizers
Int Clin Psychopharmacol. 2012; 27(5):256-6
Walpoth-Niederwanger M, Kemmler G, Grunze H, Weiss U, Hörtnagl C, Strauss R, Blasko I, Hausmann A

Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
J Clin Psychiatry. 2012; 73(7):924-30
Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Rowe M, Kupka RW, Grunze H, Goodwin FK

Impaired functioning in euthymic patients with bipolar disorder--HSV-1 as a predictor
Prog Neuropsychopharmacol Biol Psychiatry. 2012; 10:36(1):110-6
Gerber SI, Krienke UJ, Biedermann NC, Grunze H, Yolken RH, Dittmann S, Langosch JM.

Reduced negative BOLD responses in the default-mode network and increased self-focus in depression
The World Journal of Biological Psychiatry, 12, 627-637. 2011
Grimm S, Ernst J, Boesiger P, Schuepbach D, Boeker H, Northoff G

Self-regulation of cerebral blood flow by means of transcranial Doppler sonography biofeedback
Annals of Behavioral Medicine 41, 235-242. 2011
Duschek S, Schuepbach D, Doll A, Werner N & Reyes del Paso GA

Gender characteristics of cerebral hemodynamics during complex cognitive functioning
Brain and Cognition 76, 123-130. 2011
Misteli M, Duschek S, Richter A, Grimm S, Rezk M, Kraehenmann R, Boeker H, Seifritz E, Schuepbach D

Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
Int Clin Psychopharmacol. 2011; 26(2):96-106
Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J, Rowe M

2-Year course of bipolar disorder type I patients in outpatient care: factors associated with remission and functional recovery
Eur Neuropsychopharmacol. 2011; 21(4):287-9
Haro JM, Reed C, Gonzalez-Pinto A, Novick D, Bertsch J, Vieta E; EMBLEM Advisory Board

Interactions between systemic hemodynamics and cerebral blood flow during attentional processing
Psychophysiology 47, 1159–1166. 2010
Duschek S, Heiss H, Schmidt MF, Werner NS, Schuepbach D

Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder
J Clin Psychiatry. 2010; 71(9):1176-86
Post RM, Altshuler LL, Frye MA, Suppes T, Keck PE Jr, McElroy SL, Leverich GS, Luckenbaugh DA, Rowe M, Pizzarello S, Kupka RW, Grunze H, Nolen WA

Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
J Clin Psychiatry. 2010; 71(7):864-72
Post RM, Leverich GS, Kupka RW, Keck PE Jr, McElroy SL, Altshuler LL, Frye MA, Luckenbaugh DA, Rowe M, Grunze H, Suppes T, Nolen WA

Work impairment in bipolar disorder patients--results from a two-year observational study (EMBLEM)
Eur Psychiatry. 2010; 25(6):338-44
Reed C, Götz I, Vieta E, Bassi M, Haro JM; EMBLEM Advisory Board

Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network
Am J Psychiatry. 2010; 167(6):708-15
Altshuler LL, Kupka RW, Hellemann G, Frye MA, Sugar CA, McElroy SL, Nolen WA, Grunze H, Leverich GS, Keck PE, Zermeno M, Post RM, Suppes T

What works for delirious catatonic mania?
BMJ Case Rep. 2010; 15:2010
Vasudev K, Grunze H

Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells
Neuropsychopharmacology. 2010; 35(4): 893-903
Benninghoff J, Gritti A, Rizzi M, Lamorte G, Schlösser RJ, Schmitt A, Robel S, Genius J, Mössner R, Riederer P, Manji HK, Grunze H, Rujescu D, Möller HJ, Lesch KP, Vescovi AL

Rapid cerebral hemodynamic modulation during set shifting: evidence of time-locked associations with cognitive control in females
Brain and Cognition 71, 313-319. 2009
Schuepbach D, Huizinga M, Duschek S, Grimm S, Boeker H, Hell D

Preliminary results of a fine-grain analysis of mood swings and treatment modalities of bipolar I and II patients using the daily prospective life-chart-methodology.
Acta Psychiatr Scand. 2009; 120(6):474-80
Born C, Seitz NN, Grunze H, Vieta E, Dittmann S, Seemüller F, Amann B.

Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures
Human Brain Mapping 30, 2617-2627. 2009
Grimm S, Ernst J, Boesiger P, Schuepbach D, Hell D, Boeker H, Northoff G

Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression
Neuroscience Letters 456, 49-53. 2009
Heinzel A, Grimm S, Beck J, Schuepbach D, Hell D, Boesiger P, Boeker H, Northoff G

Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study.J Clin Psychiatry. 2009; 70(4):450-7
Altshuler LL, Post RM, Hellemann G, Leverich GS, Nolen WA, Frye MA, Keck PE Jr, Kupka RW, Grunze H, McElroy SL, Sugar CA, Suppes T.

Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM)
Affect Disord. 2009; 118(1-3):118-23
Vieta E, Angst J, Reed C, Bertsch J, Haro JM; EMBLEM advisory board

Does cannabis use affect treatment outcome in bipolar disorder? A longitudinal analysis
Nerv Ment Dis. 2009; 197(1):35-40
van Rossum I, Boomsma M, Tenback D, Reed C, van Os J; EMBLEM Advisory Board

Mania in the Nordic countries: patients and treatment in the acute phase of the EMBLEM study
Nord J Psychiatry. 2009; 63(4):285-91
Larsen JK, Porsdal V, Aarre TF, Koponen HJ, Aarnio J, Kleivenes OK; Emblem Advisory Board

Bipolar disorder in the elderly; different effects of age and of age of onset
J Affect Disord. 2009; 116(3):176-83
Oostervink F, Boomsma MM, Nolen WA; EMBLEM Advisory Board.

Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
Am J Psychiatry. 2009; 166(2):164-72
Frye MA, Helleman G, McElroy SL, Altshuler LL, Black DO, Keck PE Jr, Nolen WA, Kupka R, Leverich GS, Grunze H, Mintz J, Post RM, Suppes T

Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects
Neuropsychopharmacology 34, 932-943. 2009
Grimm S, Boesiger P, Beck J, Schuepbach D, Bermpohl F, Walter M, Ernst J, Hell D, Boeker H, Northoff G

Translation of randomised controlled trial findings into clinical practice: comparison of olanzapine and valproate in the EMBLEM study
Pharmacopsychiatry. 2009; 42(4):145-52
Novick D, Gonzalez-Pinto A, Haro JM, Bertsch J, Reed C, Perrin E, Tohen M; EMBLEM Advisory Board

Lamotrigine in bipolar disorder: results of a mirror-image evaluation using the NIMH Lifechart-Methodology
J Affect Disord. 2009; 115(1-2):241-5
Born C, Bernhard B, Dittmann S, Seemüller F, Grunze H

The impact of homocysteine levels on cognition in euthymic bipolar patients: a cross-sectional study
J Clin Psychiatry. 2008; 69(6):899-906
Dittmann S, Seemüller F, Grunze HC, Schwarz MJ, Zach J, Fast K, Born C, Dargel S, Engel RR, Bernhard B, Möller HJ, Riedel M, Severus WE

Use of remote centralized raters via live 2-way video in a multicenter clinical trial for schizophrenia
J Clin Psychopharmacol. 2008; 28:691-693
Grunze HC, Höschl C, Montgomery SA, Sartorius N, Vieta E. Response to Shen J, Kobak K, Zhao Y, et al

Efficacy of quetiapine monotherapy in rapid-cycling bipolar disorder in comparison with sodium valproate
J Clin Psychopharmacol. 2008; 28(5):555-60
Langosch JM, Drieling T, Biedermann NC, Born C, Sasse J, Bauer H, Walden J, Bauer M, Grunze H

Onset of depressive episodes is faster in patients with bipolar versus unipolar depressive disorder: evidence from a retrospective comparative study
J Clin Psychiatry. 2008; 69(7):1075-80
Hegerl U, Bottner AC, Holtschmidt-Täschner B, Born C, Seemüller F, Scheunemann W, Schütze M, Grunze H, Henkel V, Mergl R, Angst J

Are bipolar mood symptoms affected by the phase of the menstrual cycle?
J Womens Health (Larchmt). 2008; 17(3):473-8
Shivakumar G, Bernstein IH, Suppes T; Stanley Foundation Bipolar Network, Keck PE, McElroy SL, Altshuler LL, Frye MA, Nolen WA, Kupka RW, Grunze H, Leverich GS, Mintz J, Post RM

Cognitive functioning in euthymic bipolar I and bipolar II patients
Bipolar Disord. 2008; 10(8):877-87 
Dittmann S, Hennig-Fast K, Gerber S, Seemüller F, Riedel M, Emanuel Severus W, Langosch J, Engel RR, Möller HJ, Grunze HC

A 12-week, open, randomized trial comparing sodium valproate to lithium in patients with bipolar I disorder suffering from a manic episode
Int Clin Psychopharmacol. 2008; 23(5):254-62
Bowden C, Göğüş A, Grunze H, Häggström L, Rybakowski J

Stability and treatment outcome of distinct classes of mania
Eur Psychiatry. 2008; 23(5):360-7
van Rossum I, Haro JM, Tenback D, Boomsma M, Götz I, Vieta E, van Os J; EMBLEM Advisory Board

Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism
Schizophr Res. 2007; 97(1-3):254-6
Braun I, Genius J, Grunze H, Bender A, Möller HJ, Rujescu D.

A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities
Biol Psychiatry. 2006; 15:59(8):721-9
Rujescu D, Bender A, Keck M, Hartmann AM, Ohl F, Räder H, Giegling I, Genius J, McCarley RW, Möller HJ, Grunze H.

Serum levels of substance P and response to antidepressant pharmacotherapy
Pharmacopsychiatry. 2004; 37(5):238-9
Lieb K, Walden J, Grunze H, Fiebich BL, Berger M, Normann C.

Pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review
Prog Neuropsychopharmacol Biol Psychiatry. 2001; 25(8):1555-70
Grunze H, Langosch J, Schirrmacher K, Bingmann D, Von Wegerer J, Walden J. Kava

Short-term and long-term effects of N-methyl-D-aspartate receptor hypofunction
Arch Gen Psychiatry. 2000; 57(12):1180-1
Greene R, Bergeron R, McCarley R, Coyle JT, Grunze H.

Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal
Neuropsychobiology. 2000; 42 Suppl 1:28-32
Grunze H, Langosch J, von Löwenich C, Walden J.

New insights into the mechanisms and sites of action of lamotrigine
Neuropsychobiology. 2000; 42 Suppl 1:26-7
Langosch JM, Zhou XY, Grunze H, Walden J.

Effects of lamotrigine on field potentials and long-term potentiation in guinea pig hippocampal slices
Epilepsia. 2000; 41(9):1102-6
Langosch JM, Zhou XY, Frick A, Grunze H, Walden J.

Neurotoxicity of NMDA antagonists: a glutamatergic theory of schizophrenia based on selective impairment of local inhibitory feedback circuits
Dialogues Clin Neurosci. 2000; 2(3):287-98
Grunze H, Bender A, Wendhof S, Schäfer M, Rujescu D.

Dysregulation of ion fluxes in bipolar affective disorder
Acta Neuropsychiatrica. 2000; 12:81-85
Grunze H, Langosch J, Norman C, Rujescu D, Amann B, Walden J. 





Schizophrenien. Verständnisgrundlagen, Orientierungshilfen, für Patienten und Angehörige
Springer-Verlag, 5. Auflage. 2016
Hell D, Schüpbach D.

Psychopharmaka in der Apotheke
Wissenschaftlicher Verlag. Stuttgart. 2018
Dietmaier O, Schüpbach D.

Bipolare Affektive Störungen- Ursachen und Behandlung
G. Thieme Verlag, Stuttgart. 1.Auflage: 1998, 2.Auflage: 2000, 3.Auflage 2003, 4.Auflage 2006, 5.Auflage 2009
J. Walden, H. Grunze

Bipolare Störungen-Ratgeber für Betroffene und Angehörige
DGBS Eigenverlag, Hamburg, 2002; 2. Überarbeitete Auflage 2005
R. Geislinger, H. Grunze

Valproat bei manisch-depressiven (bipolaren) Erkrankungen
G. Thieme Verlag, Stuttgart, 1.Auflage: 2000 , 2. Überarbeitete Auflage: 2004
H. Grunze, J. Walde

Bipolar Affective Disorder- Etiology and Treatment
G.Thieme Verlag, Stuttgart, 1. Auflage 2000, 2. Auflage 2004
J. Walden, H. Grunze

Die bipolaren Störungen (Manisch-depressive Erkrankungen): Ratgeber für Betroffene und ihre Angehörigen
G. Thieme Verlag, Stuttgart, 2003
H. Grunze
, J. Walden

Untersuchungen an Adsorptionsfilmen zum Grenzflachenverhalten der Hamoglobinkomponente CTT IV von Chironomus thummi thummi in der Luft! Wasser- Grenzschicht mit einem Wilhelmy-Filmwaagesystem
Dissertation, Aachen 1989
H. Grunze





Agitation due to Substance Use, Abuse and Withdrawl. In Diagnosis and Management of Agitation
Hrsg. M. Zeller, K.Nordstrom, S.Wilson. 3rd ed. Cambridge University Press, Cambridge, 2018, pp 235-238, ISBN 978-1-108-41411-1
A. Schorb, H. Grunze

Chapter 24. Management commentary. In: Parker, G, ed.: Bipolar II Disorder. Modelling, Measuring and Managing
3rd ed. Cambridge University Press, Cambridge, 2018, pp 235-238
ISBN 978-1-108-41411-1
Grunze H

Polypharmazie in der Behandlung bipolarer Störungen. In: Polypharmazie in der Behandlung psychischer Erkrankungen
Hrsg. T.Messer, M.Schmauss. Springer Verlag, Wien New York, 2006, pp 81- 102. 2.Auflage 2009, pp 95-118, 3. Auflage 2016, pp 85-113
H.Grunze, A.Forsthoff, C.Born 

Chapter 40. Bipolar Disorder. In: Zigmond MJ, Rowland LP, Coyle JT, eds. Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders
Academic Press; 2015, pp.655–673
H. Grunze

Pharmacotherapy and dual disorders .In: Co-occurring addictive and psychiatric disorders: a practice based handbook on dual disorders within the European healthcare context
Hrsg. G.Dom, F.Moggi. Springer Verlag, New York, 2015, 279-306
M.Soyka, H.Grunze

Chapter 23. Pharmacological Treatment of Acute Bipolar Depression. In: Bipolar Disorder: Millenium Update. Hrsg. A.Yildiz, C.Nemeroff, P.Ruiz
Oxford University Press, New York, 2015, pp.281-298
K. Gao, R.Wu, H. Grunze, JR Calabrese

Chapter 32. Treatment Induced Mood Instability: Treatment – Emergent Affective Switches and Cycle Acceleration. In: Bipolar Disorder: Millenium Update
Hrsg. A.Yildiz, C.Nemeroff, P.Ruiz. Oxford University Press, New York, 2015,pp.417-434
R.Wu, K. Gao, JR Calabrese, H. Grunze

Long-term treatment of mood disorders: follow-up of acute treatment phase studies versus continuation and maintenance phase studies, and enriched versus non-enriched designs. In: Clinical Trial Design Challenges In Mood Disorders
Hrsg. M.Tohen, C.Bowden, A.Nierenberg, J.Geddes. Elsevier, Amsterdam, 2015, pp 29-47
W.A. Nolen, H. Grunze.

Optionen der Langzeittherapie bipolarer Verläufe. In: H.J.Assion, P.Brieger, M.Bauer: Bipolare Störungen. Das Praxishandbuch
Verlag W.Kohlhammer, Stuttgart 2013, pp. 167-175
H.Grunze, J.Walden

Chapter 14: The role of polypharmacy in Bipolar Disorder treatment guidelines. In: Polypharmacy in psychiatry practice, Vol II.
Hrsg. M.Ritsner. Springer Verlag, New York, 2013 pp.275-287

Medikamente zur Behandlung bipolarer Störungen. In: Handbuch der Psychopharmakotherapie, 2. Auflage
Hrsg. G.Gründer, O.Benkert.Springer Verlag, Berlin-Heidelberg, 2012, pp 629-658
H.Grunze, M.Bauer

Carbamazepine, Other Anticonvulsants and Augmenting Agents. In: Bipolar Psychopharmacology-Caring for the patient
Hrsg.H.S. Akiskal, M.Tohen. John Wiley & Sons, Chichester, 1.Auflage 2005, pp 63-84: 2.Auflage: 2011, pp 61-78

The treatment of mania. In: Practical management of bipolar Disorder
Hrsg. A.H.Young,I.N.Ferrier, E.E.Michalak. Cambridge University Press, 2010, pp 10-23

Bipolar Disorder. In: McGraw-Hill Yearbook of Science & Technology 2010
Hrsg.  M.Licker et al. McGraw-Hill, New York,2010, pp 48-50

Medikamente zur Behandlung bipolarer affektiver Störungen. In: Handbuch der Psychopharmakotherapie
Hrsg. F.Holsboer, G.Gründer, O.Benkert.Springer Verlag, Berlin-Heidelberg, 2008, pp 555-590
H.Grunze, A.Forsthoff

Mood Disorders: Depression. In : Psychiatry, Third Edition
Hrsg. A.Tasman,J.Kay, J.A.Lieberman.M.B.First.M.Maj. Wiley-Blackwell, Chichester 2008, pp 1283- 1331
H.Grunze,C. Schüle, D.Casey, T.C. Baghai

Modul Therapie akuter Episoden. In: Weissbuch bipolare Störungen in Deutschland
Hrsg. Deutsche Gesellschaft für Bipolare Störungen e.V. Eigenverlag 2002, pp 57-66; 2.Auflage  2003, pp89-130. 3.Auflage 2006, pp 161-206
H.Grunze, M.Dobmeier

Medikamentöse Therapie der Manie. In: Therapie psychischer Erkrankungen
Hrsg. H.J.Möller, G.Thieme Verlag, Stuttgart-New York,1999, pp 321-334; 3. vollständig überarbeitete Auflage 2006, pp.351-363

Antikonvulsiva. In:  Akute und therapieresistente Depressionen
2.Auflage Hrsg. M.Bauer, A.Berghöfer, M.Adli. Springer Verlag, Heidelberg,2005,pp273-284
F.Seemüller, H.Grunze

Quetiapin in der Langzeitherapie bipolarer Störungen. In: Das Quetiapin-Dossier. Pharmakologie,Indikationen, therapeutische Erfahrungen.
Hrsg. H.J. Möller. Schattauer Verlag, Stuttgart, 2005, pp 121-130

Is there a role for Typical Neuroleptics in bipolar disorder ? In: Handbook of Bipolar disorder
Hrsg. S.Kasper, R .M. Hirschfeld.Taylor& Francis, New York- London 2005, pp331- 338
H.J.Möller, H.Grunze

Toward an Integrated view: Algorithms in Bipolar disorder. In: Handbook of Bipolar disorder
Hrsg. S.Kasper, R .M. Hirschfeld.Taylor& Francis, New York- London 2005, pp 435-446

Biological aspects of rapid-cycling and mixed states. In: Bipolar Disorders- Mixed states,Rapid cycling and atypical forms
Hrsg. A.Marneros, F.Goodwin. Cambridge University Press, New York, 2005, pp311-323
H.Grunze, J.Walden

Biologische Behandlungsmethoden. In: Das Neue Handbuch der bipolaren und Depressiven Erkrankungen
Hrsg. A.Marneros. G.Thieme Verlag, Stuttgart-New York 2004, pp 225-267
H.J.Möller, M.Schmauss, H.Grunze

Biologische Grundlagen. In: Das Neue Handbuch der bipolaren und Depressiven Erkrankungen
Hrsg. A.Marneros. G.Thieme Verlag, Stuttgart-New York 2004, pp 387-402
H.Grunze, A.Rohde, A.Marneros

Elektrokonvulsionstherapie der manischen Episode im Rahmen einer bipolaren affektiven Störung. In: Elektrokunvulsionstherpie-klinische und wissenschaftliche Aspekte
Hrsg. T.C.Baghai, R.Frey,S.Kasper, H.J.Möller.Springer, Wien-New York, 2004, pp 394-405
H.Grunze, J.Scharfetter

Bipolare Störungen. In: Psychotische  Störungen
Hrsg. P.Falkai, F.G. Pajonk. G.Thieme Verlag, Stuttgart, 2003, pp 65-78

Bipolare Erkrankungen-sind moderne Neuroleptika eine neue Option?
6. Bad Homburger ZNS-Gespräche, 2003, 17-18

The search for the Holy Grail- The ideal mood stabilizer: Fiction or Future. In: Bipolar Disorder. WPA Series Evidence and Experience in Psychiatry
Hrsg. M.Maj,  H.S.Akiskal,  J.J.Lopez-Ibor,  N.Sartorius. Wiley, Chichester 2002, pp 229-232

New anticonvulsants in Bipolar Disorder: Lamotrigine, Gabapentin, Topiramate. In: Seizures, Affective Disorders and Anticonvulsant Drugs
Hrsg. M.Trimble, B.Schmitz. Clarius Press, Guildford 2002, pp 131-142
J.Walden, H. Grunze

How might anticonvulsant drugs work in bipolar affective disorder ?  In: Seizures, Affective Disorders and Anticonvulsant Drugs
Hrsg. M.Trimble, B.Schmitz. Clarius Press, Guildford 2002, pp 117- 130
H.Grunze, B.Amann, J.Walden

Erhaltungstherapie/Rezidivprophylaxe mit Antidepressiva. In: Neuro Psychopharmaka Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer
2. Neubearbeitete Auflage. Hrsg. P.Riederer, G.Laux, W. Pöldinger. Springer, Wien-New York 2002, pp 651-661
H.J. Möller, H.Grunze

Carbamazepin/Valproat: 13.2.Pharmakologie, 13.3. Neurobiochemie, Wirkmechanismus, 13.4. Klinik. In:  Neuro Psychopharmaka Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer
2. Neubearbeitete Auflage. Hrsg. P.Riederer, G.Laux, W. Pöldinger. Springer, Wien-New York 2002, pp 866-895
J.Walden, H.Grunze

Exkurs: Potentielle neue Behandlungsmöglichkeiten bipolarer affektiver Störungen. In: Neuro Psychopharmaka Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer
2. Neubearbeitete Auflage. Hrsg. P.Riederer, G.Laux, W. Pöldinger. Springer, Wien-New York 2002, pp 896- 902
H.Grunze, J.Walden

Valproinsäure in der Behandlung des manischen Syndroms und in der Prophylaxe bipolarer affektiver Störungen. In: Valproinsäure. Pharmakologie,Klinischer Einsatz, Nebenwirkungen und Therapierichtlinien
2.Auflage. Hrsg. G.Krämer, J.Walden. Springer Verlag, Berlin-Heidelberg, 2002, pp 248-255
J.Walden, C.Normann, J.Langosch, A.Erfurth, H.Grunze

Valproinsäure zur Behandlung von „rapid cycling“ und dysphorischer Manie. In: Valproinsäure.  Pharmakologie,Klinischer Einsatz, Nebenwirkungen und Therapierichtlinien
2.Auflage. Hrsg. G.Krämer, J.Walden. Springer Verlag, Berlin-Heidelberg,2002, pp 256-263
A.Erfurth, H.Grunze, J.Walden

Intravenöse Valproinsäure-Behandlung bei bipolaren Störungen. In: Valproinsäure.  Pharmakologie, Klinischer Einsatz, Nebenwirkungen und Therapierichtlinien
2.Auflage. Hrsg. G.Krämer, J.Walden. Springer Verlag, Berlin-Heidelberg, 2002, pp 264-274

Antidepressant treatment of bipolar depression. In: Bipolar disorders-100 years after manic depressive insanity
Hrsg. A.Marneros, J.Angst. Kluwer Academic Publishers, Dordrecht, 2000, pp 387-404
H.J.Möller, H.Grunze

Bedeutung der Antiepileptika in der psychiatrischen Therapie. In: Spektrum psychiatrischer Arbeit
Hrsg. K.Peter Springer Verlag Wien-New York, 2000,pp.67-74
J.Walden,C.Normann,J.Langosch,M.Berger, H.Grunze

Clinical trials of bipolar disorder. Applications and limitations. In: Anticonvulsants in Psychiatry- Round table series 64
Hrsg. N. Sussman. Royal Society of Medicine Press Ltd 1999, London, pp 17-20 (ISBN-10: 1853153788, ISBN-13: 978-1853153785)
J.Walden, H. Grunze

Störungen der glutamatergen Aktivierung limbisch-kortikaler Interneurone- ein zelluläres Psychosemodell ? In: Schizophrenie- Moderne Konzepte zu Diagnostik, Pathogenese und Therapie
Hrsg. H.J.Möller, N.Müller. Springer Verlag, Wien-New York, 1998, pp127-142
H.Grunze, C.Kammerer

Bedeutung des Calciumantagonismus in der Therapie der Epilepsien und affektiven Störungen. In: Aktuelle Perspektiven der Biologischen Psychiatrie
Hrsg. H.J.Möller, F.Müller-Spahn, G.Kurtz, Springer Verlag, Wien -New York, 1996, pp 797-800
J.Walden, D.Van Calker, J.von Wegerer, H.Grunze

Calcium antagonism as a possible common mechanism of carbamazepine effects in epilepsy and psychiatric disorders, In: Proceedings of the Second International Conference on refractory Depression (Amsterdam 1992)
Hrsg. J.Zohar,S.P.Roose, W.A.Nolen. J.Wiley &Sons, London 1992

Neurophysiologische Aspekte der Wirkung von Carbamazepin. In: Neue Aspekte zur Diagnostik und Therapie affektiver Störungen
Hrsg. H.P.Wunderlich, W.Zuckschwerdt Verlag, München-Bern-Wien-San Franzisco, 1991,pp 14-26
J.Walden,  E.J.Speckmann, D.Bingmann, U.Altrup, G.Eikmeier, H.Grunze, M.Gastpar

Reviews (R), Short Reports (SR), Fallberichte (FB), Sonstige (S)

Reviews (R), Short Reports (SR), Fallberichte (FB), Sonstige (S)

Predictors of Psychosocial Outcome of Bipolar Disorder: Results from the Stanley Foundation Bipolar Network
The Lancet Psychiatry 2018, submitted
Bennett F, Sophie Hodgetts S, Altshuler L, Close A, Frye M, Grunze H, Keck P, Kupka R, Leverich G, McElroy S, Nolen W, Post R, Schärer L, Suppes T, Sharma A

Extrapyramidal symptoms in schizophrenia: evidence of blunted cerebral hemodynamics during a planning task
International Clinical Psychopharmacology. 32:225–230. 2017 (SR)
Schuepbach D, Michel M, Wagner G, Duschek S, Herpertz SC

Hydrocephalus, psychosis and art: a case report
Schweizer Archiv für Neurologie und Psychiatrie, 166, 23-25. 2015 (FB)
Noll S, Boeker H, Roth-Greminger G, Hoff P, Schuepbach D

Arachnoid cyst in a patient with bipolar disorder: Just an incidental finding? Schweizer Archiv für Neurologie und Psychiatrie, 164, 252-254. 2013 (FB)Claussen MC, Rohde J, Seifritz E, Schuepbach D

Combined symptomatology of psychosis, pica syndrome, and hippocampal sclerosis: a case reportInternational Journal of Eating Disorders, 46, 89-91. 2013 (FB)
Rohde J, Claussen MC, Kuechenhoff B, Seifritz E, Schuepbach D

Pharmakotherapie der Bipolaren Störungen und der Manie
Zeitschrift für Psychiatrie, Psychologie und Psychotherapie, 62, 243-254. 2014 (R)
Schuepbach D, Seifritz E

BPS Fortbildungsmodul I: Aktuelle Aspekte der Diagnose und Therapie Bipolarer Störungen
Sanofi-Aventis 2006

Interview Orfiril® long – Zulassung jetzt bei akuter Manie und zur Prophylaxe bipolarer Störungen
Neuronews 2005; 4- Juni -ISSN 1619-7577

Bipolare Störungen. Fortbildungs-Medien-Akademie Psychiatrie
CME zertifiziere Fortbildungs–DVD. 2.Auflage, 2004

Interview Expertenmeinung: Bipolare Störungen-Praxisbezogene Therapie
Psycho 2004; 5: 6-7

Nachgefragt bei Dr.Heinz Grunze, 1.Vorsitzender der DGBS: Individuelle Therapiestandards (Interview)
Der Neurologe und Psychiater (DNP) 2003; 12: 7
H. Grunze

Meeting report-The 151st Annual Meeting of the American Psychiatric Association
Journal of Bipolar Disorder 1998,2 (2) 41-45  (ISSN 1460-0579)



Konflikte im Team aufdecken – Führungsinstrumente nutzen

Frau Britta Oecknigk, Studiengang Gesundheits,- und Sozialmanagement (B.A.) an der HFH (Hamburger Fernhochschule

Stationsäquivalente gerontopsychiatrische Akutbehandlung in der Häuslichkeit. Der Wunsch der Angehörigen und die Bedeutung für die Organisation

Herr Andreas Böttinger, Studiengang Pflegemanagement und Organisationswissen B.A. (Fliedner Fachhochschule Düsseldorf)



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